Potential Use of Haematopoietic or Mesenchymal Stem Cells in the Treatment of Immune Mediated Neutropenia in Domestic Canines

In domestic canines, neutrophils are the major component of white blood cells, which when reduced in numbers (neutropenia) can significantly compromise innate immune physiology. Several conditions known to cause neutropenia however is observed without any underlying cause, it suspected be mediated (IMN). Although IMN treated symptomatically using immunosuppression therapy, recent developments stem cell therapies offer therapeutic potential especially cases relapse. This brief report outlines merit haematopoietic (HSC) and/or mesenchymal (MSC) cells treatment canines. The efficacy HSC repopulate niche responsible for production bone marrow together with immunomodulatory properties MSC against IMN. Such innovative based canine’s merits clinical evaluation.